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Literature summary extracted from

  • Liu, Y.; Havinga, R.; VAN DER Leij, F.R.; Boverhof, R.; Sauer, P.J.; Kuipers, F.; Stellaard, F.
    Dexamethasone exposure of neonatal rats modulates biliary lipid secretion and hepatic expression of genes controlling bile acid metabolism in adulthood without interfering with primary bile acid kinetics (2008), Pediatr. Res., 63, 375-381.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Rattus norvegicus
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-
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1.14.14.139 Rattus norvegicus
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 pregnant Wistar rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 liver
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 Rattus norvegicus
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Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 CYP8B1
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 Rattus norvegicus
1.14.14.139 sterol 12alpha-hydroxylase
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 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.14.14.139 Rattus norvegicus neonatal dexamethasone administration disturbs development of gene expression pattern into adulthood, the ratio of Cyp7a1/Cyp8b1 mRNA level, which is markedly increased at 4 weeks of age in the control group, shows a delayed increase at 8 weeks of age in the dexamethasone-treated animals down
1.14.14.139 Rattus norvegicus dexomethasone acutely induces hepatic mRNA levels of cholesterol 7alpha-hydrol Cyp6a1, cholesterol 27-hydrolase Cyp27, and in particular sterol 12alpha-hydrolase Cyp8b1. Neonatal dexomethasone administration leads to increased biliary lipid secretion, decreased Cyp8b1 mRNA expression and a 3fold higher Cyp7a1/Cyp8b1 mRNA ratio in rats at week 8 up
1.14.14.139 Rattus norvegicus dexamethasone administration results in significantly increased hepatic gene expression of Cyp8B1 in 2 days old rats compared with age-matched controls. In control animals, hepatic Cyp8b1 gene expression increases from 4 weeks onward and reaches to its maximal level at about 24 weeks of age up